Fluconazole (Rx)

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Fluconazole (Rx)

Why our vets recommend it

Fluconazole is a highly effective treatment for a variety of fungal and yeast infections in pets with fewer side effects than many antifungal medications.

 
 
 
 

Medication information

What is Fluconazole?

Fluconazole is prescription antifungal medication that treats a variety of fungal infections in pets. It can be used to treat more serious fungal infections that impact internal organs as well as fungal skin infections, such as ringworm and yeast infections.

What does Fluconazole treat?

Conditions that Fluconazole treats in pets include:

  • Systemic fungal infections
  • Fungal infections that affect the nervous system
  • Yeast infections
  • Ringworm
  • Blastomycosis
  • Histoplasmosis

How is Fluconazole given?

Give Fluconazole tablets to your pet orally as directed by your veterinarian. 

Who is Fluconazole for?

Cats and dogs

What are the active ingredients of Fluconazole?

Fluconazole

 

This is the generic for Diflucan.

What are the possible side effects of Fluconazole?

Fluconazole is generally well tolerated by pets. The most common side effects of Fluconazole are loss of appetite, vomiting, diarrhea, lethargy, skin rash, and jaundice. Liver toxicity can occur, especially with long-term use. Reach out to your vet if your pet experiences any side effects.
 

Fluconazole may interact with other medications. Be sure to tell your vet about any medications, vitamins, or supplements that your pet is taking.

Safety Information

  • Fluconazole is generally well-tolerated, especially compared to some other antifungal drugs.
  • Possible side effects include:
    • Decreased appetite
    • Vomiting or diarrhea
    • Lethargy or tiredness
    • Elevated liver enzymes (with long-term use)
  • More rarely, pets may experience neurological symptoms like unsteadiness or seizures—especially at high doses or with underlying liver issues.
  • Routine blood work may be recommended to monitor liver health during prolonged treatment.
  • Use cautiously in pets with existing liver disease, kidney disease, or pregnant animals.

Warnings 

  • Do not use fluconazole in pets with a known allergy to this medication or other azole antifungals.
  • Let your veterinarian know if your pet is taking other medications, especially drugs that affect the liver or kidneys, or medications that rely on liver enzymes for metabolism.
  • Drug interactions can occur, so close monitoring may be required.
  • Always follow the prescription label and veterinary instructions carefully.

Human Warnings

  • Fluconazole prescribed for pets should never be used by humans.
  • People with known allergies to antifungals should avoid handling this medication.
  • Wash your hands after administering it to your pet.
  • If accidental ingestion occurs, seek medical help immediately.

 

References

  1. Fort Lee Animal Clinic. Fluconazole Handout. Fort Lee Animal Clinic, Dec. 2023, https://fortleeanimalclinic.com/wp-content/uploads/2023/12/Fluconazole-Handout.pdf. 

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