Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) antidepressant prescribed to treat a variety of behavioral issues in dogs and cats, including separation anxiety, obsessive-compulsive disorders, and aggression. This medication increases natural serotonin levels in the brain, which can help pets stay calmer, feel less anxious, and reduce aggressive behaviors. This is the generic form of Prozac. 

Fluoxetine typically takes 4 to 8 weeks to take effect and create noticeable behavioral changes, but generally causes less sedation than drugs that work faster.

Common symptoms that fluoxetine treats include:

• Whining or barking
• Pacing
• Yawning
• Destructive behavior
• Panting
• Hiding
• Trying to escape

Conditions that fluoxetine treats include:

• Separation anxiety
• Obsessive-compulsive disorders
• Aggression

Fluoxetine capsules or tablets are given orally to cats and dogs following the dosage instructions from your veterinarian. Giving it with food can prevent stomach upset.

Cats and dogs

Fluoxetine hydrochloride 

This is the generic form of Prozac.

The biggest adverse effects of fluoxetine are associated with gastrointestinal upset, including lack of appetite, vomiting, diarrhea, and/or weight loss. Other signs, although infrequent, include tremors, restlessness, and excessive vocalization. To minimize side effects, we prefer to start at a lower dose for the first few weeks.

Be sure to tell your vet about any medications, vitamins, or supplements that your pet is taking.