Simparica Trio – 6 months (Rx)

  • Prescription
  • Dogs
  • Flea & Tick
Simparica Trio – 6 months (Rx)

Why our vets recommend it

All-in-one flea, tick, heartworm, and intestinal parasite oral medication. Currently, there isn’t a single, all-in-one product on the market like it.

Total Price


($156.99 / unit)

Price Match Guarantee
Free Shipping
Get vet care and prescriptions, quickly and affordably from home
See how it works

Medication information

What is Simparica Trio?

Simparica Trio is a monthly medication that protects your dog against potentially deadly heartworm disease, five types of ticks (deer tick, American dog tick, lone star tick, brown dog tick, gulf coast tick), fleas, roundworms, and hookworms — all in one tasty, liver-flavored chewable tablet. It’s FDA-approved to block infections that may cause Lyme disease by killing deer ticks. And in a study, Simparica Trio was shown to kill fleas within 4 hours, and achieved 100% effectiveness in 8 hours.

What does Simparica Trio treat?

Simparica Trio protects dogs against:

  • Heartworm disease
  • Five types of ticks (American dog tick, lone star tick, brown dog tick, gulf coast tick)
  • Fleas
  • Roundworms
  • Hookworms

How is Simparica Trio given?

Give orally to dogs with or without food once a month.

Who is Simparica Trio for?

Dogs and puppies 8 weeks of age and older, weighing 2.8 lbs or more

What are the active ingredients of Simparica Trio?




What are the possible side effects of Simparica Trio?

The most frequently reported adverse reactions in clinical trials of Simparica Trio were vomiting and diarrhea. Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. 

How Dutch works

  • 1

    Pick a membership plan

    Choose an annual or monthly plan — starting from just $11/month.

  • 2

    Video chat with a vet today

    Pick a time and get care from a licensed vet from home.

  • 3

    Get prescriptions shipped free

    Your vet will customize a treatment plan to help your pet and we’ll ship it to you.

  • 4

    Get unlimited care & follow-ups

    Ask follow-up questions and get care for other health issues quickly online.

Annual members save $650 a year vs. other vets

  • Time to
    see a vet

  • Vet visit fee

  • Unlimited care
    for up to 5 pets

  • 24/7 video calls
    & messaging

  • Medication savings

  • Total annual savings

  • Less than 24 hours

  • FREE

  • Yes

  • Yes

  • 25% OFF

  • Save $650

other vets

  • 2 weeks

  • $100

  • No

  • No

  • No

  • $0

Take a deeper dive

Resources, tips, and advice to maximize your pet’s daily happiness