Simparica Trio – 6 months (Rx)
Flea & Tick

Simparica Trio – 6 months (Rx)

Prescription chewable for heartworm, flea, tick, roundworm, and hookworm

Simparica Trio is a monthly medication that protects your dog against potentially deadly heartworm disease, five types of ticks (deer tick, American dog tick, lone star tick, brown dog tick, gulf coast tick), fleas, roundworms, and hookworms — all in one tasty, liver-flavored chewable tablet. It’s FDA-approved to block infections that may cause Lyme disease by killing deer ticks. And in a study, Simparica Trio was shown to kill fleas within 4 hours, and achieved 100% effectiveness in 8 hours.

2.8–5.5 lbs$145.99 for 6 tablets
5.6–11 lbs$148.99 for 6 tablets
11.1–22 lbs$150.99 for 6 tablets
22.1–44 lbs$163.99 for 6 tablets
44.1–88 lbs$168.99 for 6 tablets
88.1–132 lbs$170.99 for 6 tablets
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Medication information

Why our vets love it:

All-in-one flea, tick, heartworm, and intestinal parasite oral medication. Currently, there isn’t a single, all-in-one product on the market like it.

Medication type:

Oral liver-flavored chewable tablet

How to use:

Give once a month orally with or without food

Who it’s for:

Dogs and puppies 8 weeks of age and older, weighing 2.8 lbs or more

Active ingredients:

  • Sarolaner
  • Moxidectin
  • Pyrantel

Possible side effects:

The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs.