Safety Information

NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) is for topical use only in cats. Safe for use in cats and kittens 8 weeks of age or older, weighing 1.8 lbs or more. Use with caution in cats with a history of seizures or neurologic disorders. The most frequently reported adverse reactions include vomiting, application site reactions, lethargy, and anorexia. If ingested, hypersalivation may occur. Avoid direct contact with application site until visibly dry. For more information, click here for full prescribing information.2

Prescribing Information

https://docs.boehringer-ingelheim.com/NexGard%C2%AE%20COMBO%20%28esafoxolaner%2C%20eprinomectin%2C%20and%20praziquantel%20topical%20solution%29.pdf

Warnings 

• Esafoxolaner, one of the ingredients in NexGard® COMBO, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in cats receiving isoxazoline class drugs, even in cats without a history of seizures. Use with caution in cats with a history of seizures or neurologic disorders.1

• Do not administer orally. Cats may salivate excessively if NexGard® COMBO is accidentally administered orally or is ingested through licking/grooming the application site (see Target Animal Safety).1

• The safety of NexGard® COMBO has not been tested in breeding, pregnant, or lactating cats.1

• The safety of NexGard® COMBO has not been tested in kittens less than 8 weeks of age or weighing less than 1.8 lbs (0.8 kg).1

Human Warnings

• Not for human use. Keep this and all drugs out of sight and reach of children. Avoid direct contact with application site for 4 hours or until visibly dry. This product may act as a mild to moderate eye irritant.1

• Keep product in the original packaging until use. Wash hands after product administration. If the product accidentally gets into the eyes, rinse thoroughly with water. If wearing contact lenses, flush the eyes first with water and then remove the lenses and continue to flush thoroughly with water. In case of accidental ingestion, or if skin or eye irritation occurs, contact a poison control center or physician for treatment advice.1

References

"NexGard Combo." Drugs.com, Drugs.com, www.drugs.com/vet/nexgard-combo.html.