Simparica Trio is a monthly medication that protects your dog against potentially deadly heartworm disease, five types of ticks (deer tick, American dog tick, lone star tick, brown dog tick, gulf coast tick), fleas, roundworms, and hookworms — all in one tasty, liver-flavored chewable tablet. It’s FDA-approved to block infections that may cause Lyme disease by killing deer ticks. And in a study, Simparica Trio was shown to kill fleas within 4 hours, and achieved 100% effectiveness in 8 hours.

Simparica Trio protects dogs against:

• Heartworm disease
• Five types of ticks (American dog tick, lone star tick, brown dog tick, gulf coast tick)
• Fleas
• Roundworms
• Hookworms

Give orally to dogs with or without food once a month.

Dogs and puppies 8 weeks of age and older, weighing 2.8 lbs or more

Sarolaner

Moxidectin

Pyrantel

The most frequently reported adverse reactions in clinical trials of Simparica Trio were vomiting and diarrhea. Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs.