Fluoxetine (Rx)

Fluoxetine (Rx)

Prescription medication for behavioral issues

Fluoxetine is a selective serotonin reuptake inhibitor or SSRI antidepressant prescribed to treat a variety of behavioral issues in dogs and cats, including separation anxiety, obsessive-compulsive disorders, and aggression. This medication increases natural serotonin levels in the brain, which can help pets stay calmer, feel less anxious, and reduce aggressive behaviors. This is the generic form of Prozac. Be sure to tell your vet about any medications, vitamins, or supplements that your pet is taking.

10 mg capsule$0.19 per capsule
20 mg capsule$0.49 per capsule
40 mg capsule$0.79 per capsule
10 mg tablet$1.04 per tablet
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*All prescriptions require vet approval

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Medication information

Why our vets love it:

One of the most researched and recommended behavioral medications in pets that has a great track record of success.

Medication type:

Oral capsule or tablet

How to use:

Orally following the dosage instructions from your veterinarian. Giving it with food can prevent stomach upset.

Who it’s for:

Cats and dogs

Active ingredient:

  • Fluoxetine hydrochloride

Common symptoms:

  • Whining or barking
  • Pacing
  • Yawning
  • Destructive behavior
  • Panting
  • Hiding
  • Trying to escape

What it treats:

  • Separation anxiety
  • Obsessive-compulsive disorders
  • Aggression

Possible side effects:

The biggest adverse effects are associated with gastrointestinal upset, including lack of appetite, vomiting, diarrhea, and/or weight loss. Other signs, although infrequent, include tremors, restlessness, and excessive vocalization. To minimize side effects, we prefer to start at a lower dose for the first few weeks. Be sure to tell your vet about any medications, vitamins, or supplements that your pet is taking.