Fluoxetine (Rx)

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Fluoxetine (Rx)

Why our vets recommend it

Fluoxetine is one of the most researched and recommended behavioral medications in pets that has a great track record of success.

 
 
 
 

Medication information

What is fluoxetine?

Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) antidepressant prescribed to treat a variety of behavioral issues in dogs and cats, including separation anxiety, obsessive-compulsive disorders, and aggression. This medication increases natural serotonin levels in the brain, which can help pets stay calmer, feel less anxious, and reduce aggressive behaviors. This is the generic form of Prozac. 

Fluoxetine typically takes 4 to 8 weeks to take effect and create noticeable behavioral changes, but generally causes less sedation than drugs that work faster.

What does fluoxetine treat?

Common symptoms that fluoxetine treats include:

  • Whining or barking
  • Pacing
  • Yawning
  • Destructive behavior
  • Panting
  • Hiding
  • Trying to escape

Conditions that fluoxetine treats include:

  • Separation anxiety
  • Obsessive-compulsive disorders
  • Aggression

How is fluoxetine given?

Fluoxetine capsules or tablets are given orally to cats and dogs following the dosage instructions from your veterinarian. Giving it with food can prevent stomach upset.

Who is fluoxetine for?

Cats and dogs

What is the active ingredient in fluoxetine?

Fluoxetine hydrochloride 

This is the generic form of Prozac.

What are the possible side effects of fluoxetine?

The biggest adverse effects of fluoxetine are associated with gastrointestinal upset, including lack of appetite, vomiting, diarrhea, and/or weight loss. Other signs, although infrequent, include tremors, restlessness, and excessive vocalization. To minimize side effects, we prefer to start at a lower dose for the first few weeks.

Be sure to tell your vet about any medications, vitamins, or supplements that your pet is taking.

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Safety Information

Fluoxetine should only be given under the guidance of a licensed veterinarian to the prescribed pet. 

Warnings 

  • As a selective serotonin reuptake inhibitor (SSRI), fluoxetine can increase the risk of serotonin syndrome, a potentially dangerous condition caused by exaggerated serotonin levels. Serotonin syndrome can cause inflated heart rate, tremors, dilated pupils, trouble breathing, elevated body temperature, high blood pressure, and/or hyperactivity. Serotonin syndrome generally only occurs when two or more serotonin-increasing drugs are used simultaneously. MAO inhibitors can also increase risk of serotonin syndrome when used in conjunction with SSRIs. 
  • Use of buspirone, tramadol, clomipramine, amitriptyline, or trazodone with fluoxetine can also increase the risk of serotonin syndrome.
  • Cyproheptadine, an appetite stimulant, may decrease or even reverse the effect of fluoxetine.
  • Diazepam and alprazolam may have stronger effects if used in conjunction with fluoxetine, as can beta blockers and the blood thinner clopidogrel.
  • Fluoxetine should not be used in combination with drugs that could increase the likelihood of seizures.
  • Insulin requirements may change when taking fluoxetine.
  • This medication is best not used in patients with diabetes mellitus or with seizure disorders.
  • Before discontinuing fluoxetine, pet parents should talk to their veterinarian.2

Human Warnings

  •  Fluoxetine should be administered only to the prescribed pet. Do not administer Fluoxetine to other pets or people.2

References

  1. Neilson, Jacqueline C. "Feline Aggression - Treatment with Fluoxetine." Veterinary Partner. VIN, n.d. Web. 28 May 2024. https://veterinarypartner.vin.com/default.aspx?pid=19239&id=4952744. https://www.woodward-vets.co.uk/images/downloads/medication-leaflets/Fluoxetine.pdf 
  2. "Fluoxetine Medication Leaflet." Woodward Veterinary Practice, n.d. Web. 28 May 2024. https://www.woodward-vets.co.uk/images/downloads/medication-leaflets/Fluoxetine.pdf.