Simplicef (Rx)

  • Dogs
  • Allergy

Why our vets recommend it

Simplicef is a broad-spectrum antibiotic that’s effective against a variety of bacterial infections, including skin, soft tissue, and urinary tract infections.

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Medication information

What is Simplicef?

Simplicef is a prescription medication designed to combat a variety of bacterial infections in dogs. This broad-spectrum antibiotic effectively treats infections of the skin, soft tissue, urinary tract, and more. The scored tablets are coated and odorless so they’re easy to give to your dog.

What does Simplicef treat?

Conditions that Simplicef treats include:

  • Bacterial skin infections, including wounds and abscesses
  • Bladder infections
  • Respiratory infections

How is Simplicef given?

Give Simplicef tablets orally, with or without food, following the instructions from your veterinarian. 

Who is Simplicef for?


What are the active ingredients of Simplicef?

Cefpodoxime proxetil

What are the possible side effects of Simplicef?

The most common side effects of Simplicef are vomiting, diarrhea, increased thirst, and decreased appetite. Simplicef should not be used in dogs with known allergy to cefpodoxime or to the ß-lactam (penicillins and cephalosporins) group of antibiotics.


Be sure to tell your vet about any medications, vitamins, or supplements that your pet is taking.

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