Is Simparica Trio Safe For Dogs?

Why pet owners are switching to online vet care with Dutch

  • Prescriptions delivered free to you

  • Fast access to Licensed Vets over video

  • Unlimited video visits and follow-ups

Parasite prevention is an important measure to take into consideration when caring for your furry little friends. Parasites can cause anything from scabs due to fleas, to long-term, serious diseases in your pup if you’re not careful, so understanding the nuances of parasite treatments is useful for any dog owner.

Additionally, parasites, like ticks, that attach themselves to dogs can also be harmful to humans. . If you’re already a dog parent and have not yet invested in any form of parasite treatment, talk to your vet about the best parasite preventative, which may include Simparica Trio.

Simparica Trio is a popular parasite treatment because it tackles many common dog parasites all in one go, including ticks and fleas, roundworms and hookworms, and even heartworm disease. Developed by Zoetis, Simparica Trio is just one possible option for parasite control and prevention across the market.

So, how safe is Simparica Trio for dogs? Like any medication, there can be side effects, although it is generally well-tolerated by most dogs. Read on to discover whether or not Simparica Trio might be right for your pup.

What Is Simparica Trio For Dogs?

Parasites can cause vary degrees of harm to pet health, from mild irritation to life-threatening conditions.

Simparica Trio for dogs is a chewable tablet that enhances your dog’s protection against parasites.1 Simparica Trio is an FDA-approved prescription medication that can help to prevent a number of infections caused by parasites, including those of which can lead to Lyme disease, caused by deer ticks.1 Unlike others on the market, Simparica Trio can kill a wide range of tick species and starts killing fleas within four hours of administration, preventing the fleas from laying eggs and leading to up to 100% effectiveness after 8 hours.1

This medication is designed with three ingredients proven to help your dog fend off parasites.1 The drug is in the isoxazoline class 2 and the three defensive ingredients are sarolaner, moxidectin and pyrantel.3 Sarolaner is an acaricide and an insecticide that kills fleas, ticks and mites.4 This is the ingredient that belongs to the isoxazoline class.1 Meanwhile, moxidectin is an antiparasitic drug that kills heartworm parasites and pyrantel is a nematicide that kills hookworms and roundworms.4

Heartworm disease can stem from infected mosquitos with just one bite being enough to infect your pup.1 This disease can be fatal and can affect dogs all year round with prominence in all 50 states.1 Meanwhile, ticks are often responsible for transmitting all sorts of serious diseases in dogs, including Lyme disease, so taking preventative measures is important.1

Fleas can also cause a lot of discomfort in your dog, whether it’s excessive itching, hair loss, or sores.1 Roundworms and hookworms target your dog's intestines and can also easily spread to other animals or humans cohabiting the same space as the dog, leading to unpleasant symptoms such as diarrhea, vomiting, and stomach swelling.1

Active ingredients in Simparica Trio

Advantages Of Simparica Trio For Dogs

There are numerous advantages to using Simparica Trio for dogs as your form of parasite control. Firstly, the drug is FDA-approved with a unique, innovative chewable formula that your pup will find tasty, making it easy to administer, unlike fiddly tablets that you have to hide in food.1 This protective medication works rapidly and offers a broad spectrum of protection for dogs of varying weights and sizes.

Simparica Trio Side Effects

Generally, the Simparica Trio medication is well-tolerated amongst dogs.3 Side effects are uncommon but can include vomiting, diarrhea, lethargy, loss of appetite, increased thirst and itching or skin irritation.4 If you notice any of these symptoms it is important to contact your veterinarian immediately to prevent any long lasting effects.

How To Use Simparica Trio Safely

Simparica Trio should not be used in dogs younger than eight weeks or weigh less than 2.8 lbs

If you are considering using Simparica Trio, there are a few things you should think about before administering the medication.

1. Consult Your Veterinarian

Before giving your pet any new medications, drugs, or even diet plans, it is important to talk it through with a licensed professional first. This way, your vet can help to advise you on the best action for you to take and recommend the medicine that they think best befits your pet based on their symptoms and health history.

2. Administer The Correct Dose

Usually, your veterinarian will recommend to administer the medication every 30 days in order for the parasites to be effectively prevented.1 This medication can also be given to puppies from 8 weeks old and weighing at least 2.8 lbs.1 However, as mentioned above, it is important to consult your veterinarian before giving this to your dog.

3. Monitor For Side Effects

As with any medication, it is important to watch your pup for side effects when administering any medication for the first time. Keep an eye on them and if any side effects continue to worsen or continue for a long period of time, you must consult your veterinarian or call the poison control helpline immediately. Keep your vet updated on exactly how your dog is handling the Simparica Trio so that you know what the best course of action to take is.

Simparica Trio Alternatives

Simparica Trio is generally well-tolerated by most dogs. However, there are some other alternative flea and tick care or preventative parasite medications that your veterinarian may recommend, including:

  • Bravecto
  • Credelio
  • Nexgard
  • Heartgard Plus2

Bravecto is another form of chewable tablet, however it does not cover the same breadth of species that Simparica Trio does, as it does not protect against heartworms or intestinal parasites.5 Likewise, medications like Credelio also only protect from fleas and ticks.6 Meanwhile, Heatguard Plus protects against heartworm and intestinal parasites, but not fleas and ticks,7 so it is important to understand how a combination of these medicines might be best, or whether you should go straight for Simparica Trio - as already established, your vet will know best!


Is Simparica Trio FDA-approved?

Yes, Simparica Trio is FDA-approved and often has a generally positive response with dogs.

What is the safest tick and flea treatment for dogs?

This is a difficult question to give a generalized answer to as every dog is so different and has such specific needs. Factors such as weight, age, pre-existing health conditions and sensibilities all contribute towards the correct allotment of parasite treatment.

To get an accurate understanding, it is best to provide a licensed veterinarian with all the available information you have on your dog. This way, they can assess your pet’s individual needs to determine the correct option for you and your furry friend - with so many options available on the market there is bound to be the right treatment for your pup and maybe Simparica Trio is the one!

Final Notes

If you notice your dog itching or displaying any particular symptoms of parasites, then take immediate action by scheduling an appointment with your vet. Simpirica Trio is a well-trusted, effective source of parasite control. This chewable tablet is designed to be tasty to your dog, for a low hassle, easy way to administer the medicine that is effective against a wide range of parasites, a pro in which many other alternative medicines are lacking.

Our online pet pharmacy has a variety of heartworm medications, dewormers and flea medicines to choose from, including prescription and non-prescription products. For more information on parasite treatment and preventatives, schedule a virtual vet appointment and try Dutch today.



  1. “Simparica Trio” Zoetis

  2. “Fact Sheet for Pet Owners and Veterinarian’s about Potential Adverse Events Associated with Isoxazoline Flea and Tick Products” U.S Food & Drug Administration, 13 Aug. 2021

  3. “Safety of Simparica Trio (Sarolaner, Pyrantel and Moxidectin) in heartworm-infected dogs” PubMed, 31 March 2023

  4. Stregowski, Jenna. “Simparica Trio For Dogs Might Be The Easiest Way To Protect Your Pup From Parasites” DailyPaws, 5 April 2022

  5. “Bravecto 1-Month - fluralaner tablet, chewable” Merck Sharp & Dohme Corp

  6. “About Credelio” Credelio

  7. “Heartgard” Heartgard

Memberships to keep your pet healthier

billed $132 yearly
20% off of all memberships
billed monthly

All memberships include:

  • Fast access to licensed vets
  • Virtual care for up to 5 pets
  • Customized Rx treatment plans
  • Unlimited video calls & follow-ups
  • Guaranteed low prices on medication
  • Free shipping on every order

Frequently Asked Questions

Who is Dutch?

Dutch is an online veterinary pet telehealth service, created by pet parents and board-certified veterinary specialists. We use a science-backed approach to provide pets relief for their everyday physical and behavioral health issues. Dutch connects you with licensed veterinarians over video chat and messaging to help you get care for your dog or cat quickly wherever you are — without the stress or expense of a vet visit. We also partner with pharmacies who can deliver prescription medication (in applicable states only) and over-the-counter treatments directly to your door. Dutch isn’t a veterinary practice or pharmacy, but a company that helps facilitate these services for pet parents to make veterinary care more accessible to all.

What is a visit with Dutch like?

When booking a video call with a vet, you'll be asked a few questions about your pet’s health issue. Depending on the issue, you may also be asked to fill out a longer questionnaire about their symptoms and share photographs of them so our veterinarians can better understand what’s going on. You’ll then pick an appointment time that works best for you.

During your video call, one of our licensed veterinarians will talk to you about the symptoms your pet is experiencing, ask you questions, review your pet’s medical history if you’ve provided it, and answer any questions you have. The vet will ask to see your pet and their environment. And they may ask you to perform some simple checks on them if needed.

After your video call, the vet will send you a message with a custom treatment plan to help your pet feel better, including a link to buy any recommended prescription or over-the-counter medications. Place your order and we’ll ship it free.

How much will it cost for Dutch to treat my pet?

The Dutch membership starts at $7/mo for unlimited access to the vet. No more long waits for appointments or surprise bills.

In addition to the base membership plan, our veterinarians may also recommend additional medication (Rx and/or OTC) that you will have the option of adding to your plan at an additional cost.