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Being a pet parent means caring for your dog or cat's overall health and wellness by providing them with the preventive medications they need to live a happy, healthy life. Many pet parents take their dogs to the vet annually for exams, where your vet will run blood tests to check for heartworm and other potential diseases before giving you a prescription for a heartworm prevention medication.
However, heartworm isn't the only disease-causing parasite pet parents have to worry about. Ticks, fleas, and intestinal worms can infest your dog's body, causing serious harm if not treated correctly. Unfortunately, many pet parents wait until their dog is itching or showing symptoms to take action, but some medications can prevent dangerous parasites in the first place.
Several medications are available to help prevent and treat heartworm, ticks, fleas, and worms like roundworms from harming your dog. Preventives like Simparica Trio are designed to protect your pet from parasites, and there are many Simparica Trio alternatives your vet might prescribe.
Keep reading to learn more about Simparica Trio and Simparica Trio alternatives to determine which is right for your pet.
What Is Simparica Trio?
Many diseases and illnesses are easier to prevent than treat, such as heartworm disease, Lyme disease, flea allergies, intestinal parasites, etc.
Simparica Trio is a prescription preventative medication for dogs designed to protect them from heartworm, ticks, fleas, roundworms, and hookworms.1 It's one of the most popular flea and tick care products because it protects against many parasites, including potentially deadly heartworms.
- Moxidectin: Prevents heartworm
- Sarolaner: Eliminates ticks and fleas
- Pyrantel: Treats roundworms and hookworms1
In well-controlled lab studies, Simparica Trio was proven 100% effective in preventing the growth of heartworm in dogs.2 In addition, if you see dog scabs from fleas and need fast treatment, this is one of the best solutions available. In another study, Simparica Trio was proven to kill fleas in just four hours with an effectiveness of 100% after 8 hours, ultimately killing fleas before they could lay eggs.2
And finally, in another study, this medication began killing ticks on dogs within 8 hours, drastically reducing the total number of live ticks in 24 hours.2
There's no doubt about the efficacy of Simparica Trio, but many pet parents may wonder about this medication's potential safety and side effects. Simparica Trio is considered safe and is generally well tolerated in adult dogs. In a field safety and effectiveness study, Simparica Trio was given to dogs to prevent heartworm disease.
The most common side effects found were:
- Increased thirst and urination
Of course, not every medication is right for every dog, so you should contact your vet if your dog has any adverse reactions to this medication, regardless of how mild they may seem.
Dosage & Administration
Simparica Trio is an oral medication given once monthly with a recommended dosage depending on body weight. The typical dosage is 0.54mg/lb of sarolaner, 0.011mg/lb moxidectin, and 2.27 mg/lb pyrantel.2
Of course, this is something you won't have to worry about since your vet will write you a prescription, and the box will list your dog's weight range to ensure you're getting the right dosage, depending on their weight.
As mentioned, Simparica Trio is a safe medication for the prevention of parasites in dogs. However, there are a few things to keep in mind. First of all, Simparica Trio is not designed for cats. Therefore, you should never give your cat your dog's medication. Zoetis, the company that developed Simparica Trio, has a separate product designed specifically for cats, and there are plenty of Simparica Trio alternatives for the different species.
In addition, if your dog, for any reason, doesn't consume the entire chewable, they could be at risk of parasites. If you miss a dose, give it to your pet as soon as possible, and make sure they consume the entire pill. Since Simparica Trio is a monthly preventive, it should be given on a set schedule every 30 days. If you forget, you could be putting your dog at unnecessary risk.
Like with all heartworm medicine, your dog should be screened for heartworm beforehand since this medication is not effective at eliminating existing adult heartworms.
As always, if you have any concerns, contact your vet as soon as possible.
Alternatives To Simparica Trio
While Simparica Trio is well-tolerated by most dogs, your vet may recommend Simparica Trio alternatives for any number of reasons. However, it's crucial to understand that not all offer prevention against the same parasites, so it may be worth discussing all your options with your vet to find the best one for you and your pet.
While there are technically no safer alternatives to Simparica Trio because there's the potential for side effects with any medication, your vet can determine which is best for your pet based on their health and needs. In addition, if you're looking for a cheaper alternative to Simparica Trio, you might benefit from discussing it with your vet. A few common alternatives to this effective preventive medication include the following:
If you're looking for a monthly preventive that protects your pet from heartworm, ticks, fleas, and intestinal worms, NexGard SPECTRA is a common, cheaper alternative to Simparica Trio. Another monthly chewable tablet, it contains afoxolaner, a flea and tick preventative that eliminates fleas quickly by causing paralysis and subsequent death.3
Now, it's important to remember that not all NexGard products have the same levels of protection. For instance, NexGard chewables only protect against fleas, ticks, mites, and flea tapeworms, while NexGard Spectra protects against all of those parasites plus heartworm, hookworm, roundworm, and whipworm.3
Bravecto Plus is only available for cats but can prevent fleas, ticks, intestinal worms, and heartworm. This medication offers two months of protection, but unfortunately, there isn't an alternative available for dogs.4
On the other hand, Bravecto for dogs only targets fleas and ticks, so you won't get heartworm or intestinal parasite prevention.5 However, this medication might be a good alternative to Simparica Trio if you already use a heartworm preventive.
Bravecto stands out because it offers 12 weeks' worth of protection against fleas and ticks, so you only need to give it to your dog once every three months.5 However, since it doesn't protect against heartworm, you'll need to find another solution to protect your pet from heartworm disease.
Bravecto is available in two forms — a chew and a topical solution, giving you an option for how to administer it to your pet.
Revolution Plus is a Simparica Trio alternative for cats. Of course, you should never give your cat your dog's medication because they require their own formulations. However, you can give your pet a preventive created by the same company that brought you Simparica Trio — Zoetis.
Unlike Simparica Trio for dogs, Revolution Plus for cats is a topical solution that prevents parasites, such as fleas, ticks, ear mites, roundworms, hookworms, and heartworms. With just one application a month, you can protect your cat, and it's safe for kittens as young as eight weeks old.6
Sentinel Spectrum is another alternative to Simparica Trio for dogs. These monthly chews protect against heartworm disease, dog allergies to fleas, whipworms, hookworms, roundworms, and tapeworms.7 In a study, Sentinel Spectrum was proven safe for puppies ten weeks or older. In addition, these chews were taste-tested, with results indicating 99% of dogs are willing to eat them.7
Advantage Multi is a monthly topical broad-spectrum heartworm, parasite, and flea medicine for dogs. Unfortunately, it doesn't protect against ticks, so you'll need another solution provided by your vet.8 This alternative to Simparica Trio may be best suited for dogs who don't like receiving oral medications, but it doesn't provide as much protection as other alternatives. However, one monthly dose has been proven effective at killing worms.8
When considering alternatives to Simparica Trio, what's most important is determining the level of protection you want. Simparica Trio is a favorite among vets and pet parents because it allows you to effectively protect your pet from various parasites, including heartworms, intestinal parasites, fleas, and ticks, with just one monthly chew.
However, the right option for your pet will depend on various factors, including their health, preferences, and overall needs. For instance, some dogs may not like taking chews, so other options like topicals exist. Luckily, your vet can help you find the right option, whether an alternative to Simparica Trio or multiple preventives taken around the same time every month.
Try Dutch today to learn more about parasite protection and which options are best for your pet based on their health needs.
"Simparica Trio." Zoetis Pet Care, www.simparicatriodvm.com/.
"Simparica Trio®." U.S. National Library of Medicine, www.dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=0f83bcf4-7e89-479f-a980-4cb40456ee78&type=display.
"Nexgard Spectra® Protects against Fleas, Ticks, Mites, Heartworm and Intestinal Worms." NexGard SPECTRA® | Flea, Tick, Mite, Intestinal Worm Treatment & Heartworm Prevention | NexGard Range, www.nexgard.com.au/products/nexgard-spectra.
"Flea and Tick Treatment & Heartworm Prevention for Cats: Bravecto®." Us, 27 Mar. 2023, us.bravecto.com/cats/bravecto-plus-for-cats/.
"12-Week Protection for Dogs: Bravecto®." Us, 27 Mar. 2023, https://us.bravecto.com/dogs/bravecto-for-dogs/.
"Revolution Plus." Zoetis Petcare, www.zoetispetcare.com/products/revolution-plus.
"Sentinel Spectrum Chews." Merck Animal Health USA, 2 June 2022, www.merck-animal-health-usa.com/species/canine/sentinel/sentinel-spectrum-chews.
"Advantage Multi® for Dogs." Advantage Multi® for Dogs, https://my.elanco.com/us/advantage-multi-dogs.